Guthrie received a Juris Doctor from Georgetown University Law Center, where she graduated magna cum laude in 2002. She was a member of the Arizona Alpha chapter of Pi Beta Phi.
in journalism from the University of Arizona, graduating cum laude in 1993. She graduated from Amphitheater High School in Tucson. Guthrie also spent some time in Sydney before returning to the United States. They then visited the family’s former home in nearby Beaumaris. She made the trip with her mother, Nancy, visiting her birth place at the Maternity Ward of Sandringham Hospital in Sandringham, Victoria, an affluent beachside town located 16 km (10 mi) south east of Melbourne's central business district. The first time Guthrie returned to Australia was in 2015 while working for Today, which she described as a 'lifelong dream' of hers. Savannah Clark Guthrie, named for her great-grandmother, was born in Melbourne, Australia, where her father was stationed for work. Her family returned to the United States and moved to Tucson, Arizona, two years later.